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As for the role that caffeine has in the purported benefits of the coffee enema, drinking coffee is a far more effective method for increasing the amount of caffeine in your blood (and hence causing vasodilation to potentially send toxins from the blood into the colon, or causing increased bile acid secretion to potentially facilitate liver detoxification) compared to administering it at the other end

Bertoncini-Silva C, Vlad A, Ricciarelli R, Giacomo Fassini P, Suen VMM, Zingg J-M (2024) Enhancing the bioavailability and bioactivity of curcumin for disease prevention and treatment

On a 0.25mg dose, that is a 40% error

Better Mood and Focus B12 matters when it comes to brain health

It also improves skin health and promotes overall wellness

Many are taking both